呼吸器・免疫内科学

内藤　祐二朗Yujiro Naito M.D., Ph.D.

略歴

所属学会

日本内科学会、日本呼吸器学会、日本呼吸器内視鏡学会、日本癌学会、日本肺癌学会、日本アレルギー学会

資格

認定内科医、総合内科専門医、内科指導医、呼吸器専門医、気管支鏡専門医

臨床/研究

癌免疫療法の登場により、肺癌診療は飛躍的な発展を遂げています。しかしながら、その効果は未だ不十分であり、更なる進化が求められています。免疫学研究が充実している当教室の強みを生かし、癌免疫の基礎研究に正面から向き合うとともに、呼吸器診療の中核病院である関連施設と連携し、臨床検体を用いた検証・解析にも取り組ませていただいています。

論文

• Hirai T, Naito Y(Co-first), Koyama S, et al. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer. JCI Insight. 2024 Feb 8;9(3):e166349.
• Naito Y, Koyama S, Masuhiro K, et al. Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation. Sci Adv. 2023 May 19;9(20):eade0718.
• Masuhiro K, Tamiya M, Fujimoto K, Koyama S, Naito Y, et al. Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer. JCI Insight. 2022 May 9;7(9):e157915.
• Zhu M, Huang Y, Bender ME, Girard L, Kollipara R, Eglenen-Polat B, Naito Y, et al. Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Cancer Res. 2021 Apr 1;81(7):1813-1826.
• Naito Y, Osa A, Masuhiro K, Hirai T, Koyama S, Kumanogoh A. Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood. J Vis Exp. 2020 Feb 5;(156).
• Briones JC, Espulgar WV, Koyama S, Yoshikawa H, Park J, Naito Y, Kumanogoh A, Tamiya E, Takamatsu H, Saito M. A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling. Theranostics. 2020 Jan 1;10(1):123-132.
• Munakata L, Tanimoto Y, Osa A, Meng J, Haseda Y, Naito Y, et al. Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice. J Control Release. 2019 Nov 10;313:106-119.
• Osa A, Uenami T, Naito Y, et al. Monitoring antibody binding to T cells in a pembrolizumab-treated patient with lung adenocarcinoma on hemodialysis. Thorac Cancer. 2019 Nov;10(11):2183-2187.
• Miret JJ, Kirschmeier P, Koyama S, Zhu M, Li YY, Naito Y, et al. Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. J Immunother Cancer. 2019 Feb 6;7(1):32.
• Osa A, Uenami T, Koyama S, Fujimoto K, Okuzaki D, Takimoto T, Hirata H, Yano Y, Yokota S, Kinehara Y, Naito Y, et al. Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients. JCI Insight. 2018 Oct 4;3(19):e59125.
• Naito Y, Tamiya A, Tamiya M, et al. Efficacy of nanoparticle albumin-bound paclitaxel regimens for relapsed small cell lung cancer: A retrospective analysis. Medicine (Baltimore). 2017 Sep;96(35):e7884.

受賞歴